Evaluation of Antiinflammatory Activity of Methanol Extract of Phyllanthus amarus in Experimental Animal Models

The effects of methanol extract of Phyllanthus amarus on different phases of in lammation were examined. Investigations were performed using different phlogistic agents-induced paw e ema, carrageenan-induced airpouch inflammation and cotton pellet granuloma in rats. Methanol extract of Phyllanthus amarus significantly inhibited carrageenan, bradykinin, serotonin and prostaglandin E1-induced paw edema, but failed to inhibit the histamine-induced paw edema. Maximum inhibition was observed in prostaglandin E1-induced paw edema. In carrageenan air-pouch model, methanol extract of Phyllanthus amarus significantly reduced the volume of exudate and migration of neutrophils and monocytes. The extract significantly decreased formation of granuloma tissue in chronic inflammation model. The present study revealed that methanol extract of Phyllanthus amarus inhibits all the phases of inflammation.